The main campus of Diné College is located at Tsaile (Tsééhílí), Arizona, the “place where the stream flows into the canyon.” Sites at Window Rock, Chinle, and Tuba City serve Arizona residents, while a branch campus at Shiprock and a Site at Crownpoint serves New Mexico residents.

General Education program courses are offered at all sites and each site offers limited degree programs. The main sources of revenue for the College come from the Bureau of Indian Affairs and from the Navajo Nation. The states of Arizona and New Mexico, plus grants from public and private sources augment Diné College’s revenue.